A SIMPLE EVOLUTIONARY MODEL FOR CANCER CELL POPULATION AND ITS IMPLICATIONS ON CANCER THERAPY

作者：Yao Peng^*; Wen Shutang; Li Baoshun; Li Yuxiao

来源：Modern Physics Letters B, 2009, 23(25): 2999-3011.

DOI：10.1142/S0217984909021077

• Quasispecies
• games theory
• differentiation arrest
• genotype-phenotype link

We established a simple evolutionary model based on the cancer stem cell hypothesis. By taking cellular interactions into consideration, we introduced the evolutionary games theory into the quasispecies model. The fitness values are determined by both genotypes and cellular interactions. In the evolutionary model, a cancer cell population can evolve in different patterns. For single peak intrinsic fitness landscape, the evolution pattern can transit with increasing differentiation probability from malignant cells to benign cells in four different modes. For a large enough value of differentiation probability, the evolution is always the case that the malignant cells extinct ultimately, which might give some implications on cancer therapy.

• 出版日期2009-10-10
• 单位新乡学院; 郑州大学