Mitochondrial regulation of cell death in the Drosophila ovary

作者：Tanner Elizabeth A; McCall Kimberly^*

来源：Autophagy, 2011, 7(7): 793-794.

DOI：10.4161/auto.7.7.15695

• Drosophila
• oogenesis
• programmed cell death
• mitochondria
• Bcl-2
• autophagy
• apoptosis
• caspase
• mitochondrial fission and fusion

Interactions between the Bcl-2 family proteins and the mitochondrial fission and fusion machinery regulate cell death in mammals and worms. In Drosophila, the Bcl-2 family proteins have not been shown to be major regulators of cell death. However, emerging evidence suggests that mitochondrial remodeling may be important in Drosophila cell death. We recently demonstrated a series of events that occur during follicle removal in the Drosophila ovary that included mitochondrial remodeling and clustering, followed by uptake and degradation in the follicle cells. Importantly, the Bcl-2 family proteins, mitochondrial dynamics and autophagic proteins regulate these events.

• 出版日期2011-7