A simple and efficient synthesis of 1,3,5-tris[2-(3,5-diethynylphenyl)ethynyl]benzene from 1,3,5-triethynylbenzene

作者：Li Jie; Huang Pengcheng^*

来源：Research on Chemical Intermediates, 2012, 38(2): 403-411.

DOI：10.1007/s11164-011-0356-1

• 1,3,5-Tris[2-(3,5-diethynylphenyl)ethynyl]benzene
• Dendrimer
• Sonogashira cross-coupling
• 1,3,5-Triethynylbenzene
• Deprotection reaction

A concise and convenient three-step process is reported for preparation of 1,3,5-tris[2-(3,5-diethynylphenyl)ethynyl]benzene from 1,3,5-triethynylbenzene and 2-hydroxypropyl group-protected peripheral monomers via a Sonogashira coupling-deprotection reaction sequence. This approach had several advantages, for example high yields, short reaction time, and simple separation procedure. In the key step a modified Sonogashira reaction was developed, under which conditions the coupling of 1,3,5-triethynylbenzene and substituted iodobenzenes proceeded rapidly, giving the desired products in good to excellent yields.

• 出版日期2012-2
• 单位北京航空航天大学