Alkyne-azide click chemistry mediated carbanucleosides synthesis

作者：Broggi Julie; Joubert Nicolas; Aucagne Vincent; Berteina Raboin Sabine; Diez Gonzalez S; Nolan Steve; Topalis Dimitri; Deville Bonne Dominique; Balzarini Jan; Neyts Johan; Andrei Graciela; Snoeck Robert; Agrofoglio Luigi A^*

来源：Nucleosides Nucleotides & Nucleic Acids, 2007, 26(10-12): 1391-1394.

DOI：10.1080/15257770701534139

• click chemistry
• Huisgen cycloaddition
• carbanucleosides
• alkyne-azide

Hitherto unknown 1,4-disubstituted-[1,2,3]-triazolo-4',4'-dihydroxymethyl-3'-deoxycarbanucleosides were synthesized based on a "click approach." Various alkynes were introduced on a key azido intermediate by the "click" 1,3-dipolar Huisgen cycloaddition. Their antiviral activities and cellular toxicities were evaluated on vaccinia virus. None of the synthesized compounds exhibited a significant antiviral activity.

• 出版日期2007
• 单位河北医科大学