New Concepts in Complex Regional Pain Syndrome

作者：Tajerian Maral; Clark John David^*

来源：Hand Clinics, 2016, 32(1): 41-+.

DOI：10.1016/j.hcl.2015.08.003

• Complex regional pain syndrome
• Preclinical models
• Basic mechanisms
• Neuroinflammation
• Autoimmunity
• CNS plasticity
• Disease progression

Despite the severe pain and disability associated with complex regional pain syndrome (CRPS), the lack of understanding of the pathophysiological mechanisms supporting this enigmatic condition prevents the rational design of new therapies, a situation that is frustrating to both the physician and the patient. The review highlights some of the mechanisms thought to be involved in the pathophysiology of CRPS in preclinical models and CRPS patients, with the ultimate goal that understanding these mechanisms will lead to the design of efficacious, mechanism-based treatments available to the clinic.

• 出版日期2016-2