D-Allose Attenuates Overexpression of Inflammatory Cytokines after Cerebral Ischemia/Reperfusion Injury in Gerbil

作者：Shinohara Natsuyo; Nakamura Takehiro^*; Abe Yuko; Hifumi Toru; Kawakita Kenya; Shinomiya Aya; Tamiya Takashi; Tokuda Masaaki; Keep Richard F; Yamamoto Tohru; Kuroda Yasuhiro

来源：Journal of Stroke and Cerebrovascular Diseases, 2016, 25(9): 2184-2188.

DOI：10.1016/j.jstrokecerebrovasdis.2016.01.030

• Ischemia
• reperfusion
• D-allose
• inflammation
• cytokines
• oxidation
• hyperactivity

Background: The present study investigates the effects of D-allose, a rare sugar, on the inflammatory response after transient forebrain ischemia in the gerbil and whether it reduces oxidative stress (8-hydroxyl-2'-deoxyguanosine levels) and behavioral deficits. Methods: Transient forebrain ischemia was induced by occlusion of the bilateral common carotid arteries for 5 minutes. D-Allose was intraperitoneally injected immediately after ischemia (400 mg/kg). Inflammatory cytokines and oxidative damage in the hippocampus and behavioral deficits were examined 3 days after ischemia. Results: D-Allose administration reduced ischemia-induced cytokine production, oxidative stress, and behavioral deficits (motor and memory related). Conclusions: The present results suggest that D-allose reduces brain injury after transient global ischemia by suppressing inflammation as well as by inhibiting oxidative stress.

• 出版日期2016-9