A multicentre study on high-frequency ultrasound evaluation of the skin and joints in patients with psoriatic arthritis treated with infliximab

作者：De Agustin J J^*; Moragues C; De Miguel E; Moeller I; Acebes C; Naredo E; Uson J; Rejon E; Mayordomo L; Garrido J

来源：Clinical and Experimental Rheumatology, 2012, 30(6): 879-885.

• musculoskeletal ultrasound
• psoriatic arthritis
• inflammation
• TNF-alpha
• ultrasonography

Objective %26lt;br%26gt;Our objective was to describe the ultrasound features of patients with PsA in joints and skin and their changes after treatment with infliximab. %26lt;br%26gt;Methods %26lt;br%26gt;Eight hospitals recruited PsA active patients. Clinical (joint count for pain, TJC, and swelling, SJC, pain VAS, ESR, C-reactive protein and PASI) and US variables (plaque thickness, PD signal of dermal lesions, synovitis, erosions, and PD signal, assessed by 4-category ordinal scales) were independently recorded at baseline and 4, 12 and 24-week after starting treatment with infliximab. The results were analysed with paired t-test, Wilcoxon test, ANOVA and marginal homogeneity test. %26lt;br%26gt;Results %26lt;br%26gt;Changes in 24 patients from baseline to last available data were significant for clinical variables, pain VAS, TJC and SJC as well as for ESR, CRP (all p%26lt;0.0005). Dermatological PASI changed from 14.6 +/- 14.9 to 2.1 +/- 4.1 and plaque thickness front 3.34 +/- 1.75 mm to 1.74 +/- 0.96 mm (both p%26lt;0.0005); synovitis and PD signal improved (both p%26lt;0.0005). Psoriatic plaque PD improved across the study (p%26lt;0.0005) with no signal increasing from 36.4% to 88.9% and positive PD signal decreasing from 63.6% to 11.1% of the plaques %26lt;br%26gt;Conclusion %26lt;br%26gt;Treatment with anti-TNF-alpha infliximab improves the symptoms of patients with PsA at joint and psoriatic skin levels from a clinical and ultrasonographic perspective.

• 出版日期2012-12