An improved method for the regioselective synthesis of highly substituted quinolines from Morita-Baylis-Hillman adducts

作者:Zeoly Lucas A; Barcelos Rosimeire C; Rodrigues Manoel T Jr; Gomes Ralph C; Coelho Fernando*
来源:Tetrahedron Letters, 2015, 56(22): 2871-2874.
DOI:10.1016/j.tetlet.2015.03.090

摘要

The synthesis of highly substituted quinolines was accomplished through a Heck reaction of substituted iodoanilines with Morita-Baylis-Hillman (MBH) adducts employing Najera N-oxime derived palladacycle as catalyst. The reaction is completely regioselective and gives the products with good to excellent yields (up to 89%) with low catalyst loading and TONs of up to 89.

  • 出版日期2015-5-27