AKR1B10 is Associated with Smoking and Smoking-related Non-small-cell Lung Cancer

作者：Kang M W; Lee E S; Yoon S Y; Jo J; Lee J; Kim H K; Choi Y S; Kim K; Shim Y M; Kim J; Kim H^*

来源：Journal of International Medical Research, 2011, 39(1): 78-85.

• LUNG CANCER
• SMOKING
• BIOMARKER
• MRNA
• AKR1B10

This prospective study explored the relationship between expression of AKR1B10 mRNA and various clinical parameters in non-small-cell lung cancer (NSCLC) in terms of its validation as a marker for NSCLC. Tumour tissue samples were collected from 229 patients with NSCLC. Tissue samples from adjacent nonmalignant lung tissue (> 5 cm from the tumour) of 89 of these patients and samples from 20 patients with benign lung disease were used as controls. Quantitative reverse transcription-polymerase chain reaction showed significantly higher levels of AKR1B10 mRNA expression in NSCLC tumour tissue than in adjacent non-malignant lung tissue and benign lung tissue. Statistically significant factors for AKR1B10 mRNA over-expression were found to be male gender, smoking, squamous cell carcinoma and moderate or poor cell differentiation. It is concluded that AKR1B10 seems to have potential as a prognostic marker for NSCLC and warrants further investigation.

• 出版日期2011-2