A retrospective study of serum beta-hydroxybutyric acid in 215 ill cats: Clinical signs, laboratory findings and diagnoses

作者：Aroch Itamar^*; Shechter Polak M; Segev Gilad

来源：Veterinary Journal, 2012, 191(2): 240-245.

DOI：10.1016/j.tvjl.2011.01.010

• beta-hydroxybutyric acid
• Ketones
• Feline
• Hepatic lipidosis
• Diabetes mellitus
• Diabetic ketoacidosis
• Hyperketonaemia

Serum concentrations of p-hydroxybutyric acid (sBHBA) are increased in cats with diabetes mellitus (DM), diabetic ketoacidosis (DKA) and hepatic lipidosis (HL). This study assessed sBHBA as a diagnostic tool in 215 consecutively-enrolled ill cats in the general population in a veterinary hospital. At the time of presentation, sBHBA was within the reference range in 158/215 (73.5%) cats (median 0.27; range 0.00-0.49 mmol/L) and elevated in 57/215 (26.5%) cats (median 0.87; range 0.51-21.45 mmol/L).
Compared to cats with normal sBHBA, those with increased sBHBA had higher frequencies of anorexia, weight loss, icterus, polyuria/polydipsia, hyperbiliribinaemia, hypertriglyceridaemia, pancreatitis, HL, DM and DKA. They had higher concentrations of bilirubin and triglycerides and lower concentrations of potassium, chloride and total protein. There were positive correlations (P < 0.01) between sBHBA and urinary glucose (r = 0.42) and ketones (r = 0.76), but there were no group differences in dipstick levels of urinary ketones. Cats with DM/DKA and with HL had significantly higher sBHBA compared to other cats. Receiver operator characteristics analysis of sBHBA as a predictor of HL showed that sBHBA was a good predictor of HL Increased sBHBA occurs frequently in ill cats and provides useful diagnostic information, especially in DM/DKA and HL.

• 出版日期2012-2