Gold Nanoparticles for Nucleic Acid Delivery

作者：Ding Ya; Jiang Ziwen; Saha Krishnendu; Kim Chang Soo; Kim Sung Tae; Landis Ryan F; Rotello Vincent M^*

来源：Molecular Therapy, 2014, 22(6): 1075-1083.

DOI：10.1038/mt.2014.30

Gold nanoparticles provide an attractive and applicable scaffold for delivery of nucleic acids. In this review, we focus on the use of covalent and noncovalent gold nanoparticle conjugates for applications in gene delivery and RNA-interference technologies. We also discuss challenges in nucleic acid delivery, including endosomal entrapment/escape and active delivery/presentation of nucleic acids in the cell.

• 出版日期2014-6
• 单位中国药科大学