Neurobiological evidence for attention bias to food, emotional dysregulation, disinhibition and deficient somatosensory awareness in obesity with binge eating disorder

作者：Aviram-Friedman, Roni^*; Astbury, Nerys; Ochner, Christopher N.; Contento, Isobel; Geliebter, Allan

来源：Physiology & Behavior, 2018, 184: 122-128.

DOI：10.1016/j.physbeh.2017.11.003

• Obesity
• Binge eating disorder (BED)
• fMRI
• Brain
• Disinhibition
• Neural activation

Objectives: To refine the biobehavioral markers of binge eating disorder (BED).
Methods: We conducted fMRI brain scans using images of high energy processed food (HEPF), low energy unprocessed food (LEUF), or non-foods (NF) in 42 adults (obese with BED [obese -BED; n = 13] and obese with no BED [obese-non-BED; n = 29]) selected via ads. Two blood oxygenated level dependent (BOLD) signal contrast maps were examined: food versus nonfood, and HEPF versus LEUF. In addition, score differences on the disinhibition scale were correlated with BOLD signals.
Results: food versus nonfood showed greater BOLD activity for BED in emotional, motivational and somatosensory brain areas: insula, anterior cingulate cortex (ACC), Brodmann areas (BA) 19 & 32, inferior parietal lobule (IPL), posterior cingulate cortex (PCC), and lingual, postcentral, middle temporal and cuneate gyri (p <= 0.005; k >= 88). HEPF versus LEUF showed greater BOLD activity for BED in inhibitory brain regions: BA 6, middle and superior frontal gyri (p < 0.01; k >= 119). The groups also differed in the relationships between disinhibition and BOLD activity in the postcentral gyrus (PCG; p = 0.04) and ACC-BA 32 (p = 0.02). For all participants jointly, PCG BOLD amplitude predicted greater disinhibition (p = 0.04).
Discussion: Food images elicited neural activity indicating attention bias (cuneate & PCG), emotion dysregulation (BA 19 & 32), and disinhibition (MFG, BA6 & SFG) in obese with BED. These may help tailor a treatment for the obesity with BED phenotype.

• 出版日期2018-2-1
• 单位南宁师范大学