A 1,3-phenyl-linked hydantoin oligomer scaffold as a beta-strand mimetic

作者：Jamieson Andrew G^*; Russell David; Hamilton Andrew D

来源：Chemical Communications, 2012, 48(31): 3709-3711.

DOI：10.1039/c2cc30295k

A synthetic scaffold that mimics a peptide beta-strand has been designed and synthesised based on a 1,3-phenyl-linked hydantoin oligomer. The conformational preferences of this oligomer were investigated using molecular modelling and solution NMR experiments and suggest a planar conformation that accurately mimics the i, i + 2 and i + 4 residues of a peptide beta-strand.

• 出版日期2012