Use of a high b-value for diffusion weighted imaging of peritumoral regions to differentiate high-grade gliomas and solitary metastases

作者：Han, Chengkun; Huang, Shumin; Guo, Jianfeng; Zhuang, Xiongjie; Han, Haiwei^*

来源：Journal of Magnetic Resonance Imaging, 2015, 42(1): 80-86.

DOI：10.1002/jmri.24747

• high-grade glioma
• solitary metastasis
• standard b-value
• high b-value
• diffusion-weighted imaging

BackgroundTo determine whether apparent diffusion coefficient (ADC) values obtained using a b-value of 3000 s/mm(2) can be used to differentiate high-grade glioma (HGG) from solitary metastases (SM). @@@ MethodsForty patients underwent conventional magnetic resonance imaging (MRI) and standard and high b-value diffusion-weighted imaging (DWI). Minimum, maximum, and mean ADC values (ADC(MIN), ADC(MAX), and ADC(MEAN), respectively) were measured from ADC maps obtained for the two b-values for each subject. ADC ratios were also measured. A receiver operating characteristic (ROC) curve analysis was used to determine the cutoff ADC value for distinguishing between HGG and SM. @@@ ResultsAll ADC values for the peritumoral region of the HGGs examined were lower than those for the SM. Furthermore, a larger statistical difference was observed for ADC(MIN), ADC(MAX), and ADC(MEAN) values at a b-value of 3000 s/mm(2) versus 1000 s/mm(2) (P<0.0001, P=0.0010, and P=0.0001 versus P=0.0001, 0.0030, and 0.0002, respectively). A discriminant analysis identified the greatest log likelihood for the ADC(MIN) values obtained at a b-value of 3000 s/mm(2), and the cutoff value for differentiating HGG and SM was 0.890 x 10(-3) mm/s(2). @@@ ConclusionADC values from DWI using a high b-value were found to distinguish HGG and SM. The lowest degree of overlap was obtained when an ADC(MIN) value was obtained at a b-value of 3000 s/mm(2). J. Magn. Reson. Imaging 2015;42:80-86.

• 出版日期2015-7
• 单位厦门大学