Novel t(1;2)(p36.1;q23) and t(7;19)(q32;q13.3) chromosomal translocations in ischemic fasciitis: expanding the spectrum of pseudosarcomatous lesions with clonal pathogenetic link

作者：Sachak Taha; Heerema Nyla A; Mayerson Joel; Payne Jason E; Parwani Anil; Iwenofu O Hans^*

来源：Diagnostic Pathology, 2018, 13(1): 18.

DOI：10.1186/s13000-018-0695-y

• Ischemic fasciitis
• Pseudosarcoma
• Clonal chromosomal translocations

Background: Ischemic fasciitis is a distinctive pseudosarcomatous entity with a marked predilection for elderly and physically debilitated or immobilized patients. The etiology of these lesions is unknown but felt to be related to ischemic vascular events.
Case presentation: Herein, we report for the first time, two cytogenetic translocations, t(1;2)(p36.1;q23) and t(7;19) (q32;q13.3) in a 75 year-old ambulating female with a history of left total hip arthroplasty 20 years ago.
Conclusion: These translocations suggest a possible clonal pathogenetic link though their significance remains to be established.

• 出版日期2018-3-2