A phenacrylate scaffold for tunable thiol activation and release

作者:Sankar Rathinam K; Kumbhare Rohan S; Dharmaraja Allimuthu T; Chakrapani Harinath*
来源:Chemical Communications, 2014, 50(97): 15323-15326.
DOI:10.1039/c4cc07343f

摘要

A thiol-selective 2-methyl-3-phenacrylate scaffold with spatio-temporal control over delivery of a cargo is reported. The half-lives of decomposition could be tuned from 30 min to 1 day and the scaffold%26apos;s utility in thiol-inducible fluorophore release in cell-free as well as within cells is demonstrated.

  • 出版日期2014