Association between HLA-IIgene polymorphism and Helicobacter pylori infection in Asian and uropean population: A meta-analysis

作者：Wang, Jingqiu; Zhang, Qun; Liu, Yali; Han, Jian; Ma, Xingming; Luo, Yanping; Liang, Yaling; Zhang, Lifeng; Hu, Yonghao^*

来源：Microbial Pathogenesis, 2015, 82: 15-26.

DOI：10.1016/j.micpath.2015.03.011

• Helicobacter pylori
• HLA-IIalleles
• Susceptibility
• Meta-analysis

Background: It is generally considered that HLA-II genes contribute to the Helicobacter pylori (Hp) infection and disease development process.
Aims: To perform a meta-analysis to explore the relationship between HLA-IIgene polymorphism and host susceptibility to Hp infection.
Methods: Relevant cohort studies, case-control studies and cross-sectional studies were identified by searching Cochrane Library, PubMed, EMBASE, Web of Science and CBM up to July 2014. The data were extracted and methodological quality of the studies were evaluated. RevMan5.0 software was used to perform statistical analysis.
Results: In Asian population, HLA-DQB1*0303 acted as the protective gene in Hp infection (statistically significant pooled OR = 0.54) and the susceptible genes in Hp infection involved HLA-DQB1*0401, HLA-DQA1*0103 and HLA-DQA1*0301 (statistically significant pooled OR and 95%Cl were 334(1.93,5.77), 1.64(1.16,2.33) and 2.03(1.20,3.44) respectively). No statistically significant difference between DQB1*0303, HLA-DQA1*0103 and DQA1*0301 and Hp infection in European population (P>0.05). And no statistically significant difference (P>0.05) in the overall effect of the association between the rest of HLA-IIalleles and Hp infection.
Conclusions: In Asian population, the protective gene HLA-DQB1*0303 and the susceptible genes HLA-DQB1*0401, HLA-DQA1*0103 and HLA-DQA1*0301 in Hp infection were established by meta-analysis. And there was no HLA-IIallele was found to associate with Hp infection among European population.

• 出版日期2015-5
• 单位甘肃农业大学; 兰州大学