A Novel Regulator of Type II Diabetes: MicroRNA-143

作者：Li Biao; Fan Jingjing; Chen Ning^*

来源：Trends in Endocrinology and Metabolism, 2018, 29(6): 380-388.

DOI：10.1016/j.tem.2018.03.019

• ORP8
• T2DM
• exercise intervention
• insulin resistance
• miR-143

MiR-143 is an miRNA with the function of specifically inhibiting the insulin-AKT pathway via the downregulation of oxysterol-binding protein-related protein 8 (ORP8), thus resulting in the inhibition of AKT phosphorylation, insulin tolerance, and final development of type II diabetes mellitus (T2DM). Aerobic exercise can prevent T2DM by downregulating miR-143. However, the underlying mechanisms for exercise-induced change of miR-143 remain unclear. In the present study, we will summarize the involvement of miR-143 in regulating the development of T2DM and the underlying mechanisms for potential diagnosis, prevention, and treatments, including exercise intervention for T2DM by targeting miR-143.

• 出版日期2018-6
• 单位武汉体育学院