Autologous attenuated T-cell vaccine (Tovaxin (R)) dose escalation in multiple sclerosis relapsing-remitting and secondary progressive patients nonresponsive to approved immunomodulatory therapies

作者：Loftus B; Newsom B; Montgomery M; Von Gynz Rekowski K; Riser M; Inman S; Garces P; Rill D; Zhang J; Williams J C^*

来源：Clinical Immunology, 2009, 131(2): 202-215.

DOI：10.1016/j.clim.2009.01.005

• Multiple sclerosis
• T-cell vaccination
• Myelin reactive T-cells

An open-label dose escalation study of T-cell vaccination in multiple sclerosis patients was conducted using attenuated myelin reactive T-cells (MRTC) selected with six myelin peptides, two each from MBP, PLP and MOG. The dose range of subcutaneous injections given at weeks 0, 4, 12 and 20 was 6-9E6, 30-45E6 and 60-90E6 irradiated MRTC. Assessments were over 52 weeks for MRTC levels, EDSS, MSIS-29, brain MRI and relapses. The 30-45E6 dose was the most effective with reductions in MRTC ranging from 92.4% at week 5 to 64.8% at week 52. The reduction in relapses compared to baseline for the M-ITT and evaluable per-protocol analyses were 63.5%, and 85.0% at week 52. The MRI lesions were stable white there was an improvement trend in the EDSS and MSIS29 physical subscore following the second injection. Adverse events were mild to moderate in intensity with mild injection site reactions occurring with increasing dosage. The mid-dose was selected for further clinical development studies because of the rapid depletion of peripheral blood MRTC and a trend for improvements in clinical outcomes following immunization.

• 出版日期2009-5