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摘要
Despite the biological relevance of complexes of various transition metals, tantalum complexes have long been neglected by bioinorganic chemists. Herein, we demonstrate potential chemotherapeutic applicability of the [Ta((5)-Cp*)Cl-2(salaph)] (1) complex, containing deprotonated Schiff base 2-{(E)-[(2-hydroxyphenyl)imino]methyl}phenol (H(2)salaph), which shows strong cytotoxicity in cancer cells, related to the induction of apoptosis and apoptosis-related processes, but shows low cytotoxicity in healthy cells.
- 出版日期2018-9-4
