Postoperative Radiotherapy for Gallbladder Cancer

作者：Jeong Yuri; Park Jin Hong^*; Lee Young Joo; Park Kwang Min; Hwang Shin; Chang Heung Moon; Kim Kyu Pyo; Yoon Sang Min; Jung Nuri Hyun; Kim Jong Hoon

来源：Anticancer Research, 2014, 34(10): 5621-5629.

• Gallbladder cancer
• postoperative radiotherapy
• chemotherapy

Aim: To evaluate the results of postoperative radiotherapy (PORT) and to identify prognostic factors for gallbladder cancer (GBC). Patients and Methods: We retrospectively analyzed 86 patients with GBC who underwent potentially curative surgical resection and PORT between November 1993 and December 2009. All patients received three-dimensional conformal radiotherapy and 61 patients (71%) had concurrent chemotherapy. Survival outcomes including locoregional control (LRC) disease-free survival (DES) and overall survival (OS) rates were analyzed. Results: The median follow-up period was 83 months for surviving patients. The 5-year OS, DES and LRC rates were 42%,36% and 73%, respectively. Isolated locoregional recurrence as first failure occurred in seven patients (8%). On multivariate analysis, the postoperative carbohydrate antigen 19-9 (CA 19-9) level was a significant prognostic factor for LRC, DES and OS. Conclusion: Adjuvant radiotherapy might be an eftective treatment in terms of LRC in GBC. Postoperative CA 19-9 might be useful as a surrogate marker for survival.

• 出版日期2014-10