A Fibrocontractive Mechanochemical Model of Dermal Wound Closure Incorporating Realistic Growth Factor Kinetics

作者：Murphy Kelly E^*; Hall Cameron L; Maini Philip K; McCue Scott W; McElwain D L Sean

来源：Bulletin of Mathematical Biology, 2012, 74(5): 1143-1170.

DOI：10.1007/s11538-011-9712-y

• Biomechanics
• Myofibroblasts
• Transforming growth factor-beta
• Contraction

Fibroblasts and their activated phenotype, myofibroblasts, are the primary cell types involved in the contraction associated with dermal wound healing. Recent experimental evidence indicates that the transformation from fibroblasts to myofibroblasts involves two distinct processes: The cells are stimulated to change phenotype by the combined actions of transforming growth factor beta (TGF beta) and mechanical tension. This observation indicates a need for a detailed exploration of the effect of the strong interactions between the mechanical changes and growth factors in dermal wound healing. We review the experimental findings in detail and develop a model of dermal wound healing that incorporates these phenomena. Our model includes the interactions between TGF beta and collagenase, providing a more biologically realistic form for the growth factor kinetics than those included in previous mechanochemical descriptions. A comparison is made between the model predictions and experimental data on human dermal wound healing and all the essential features are well matched.

• 出版日期2012-5