Anti-inflammatory Activity of Aristotelia chilensis Mol. (Stuntz) (Elaeocarpaceae).

作者：Cespedes Carlos L^*; Alarcon Julio; Avila Jose G; Nieto Antonio

来源：Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas, 2010, 9(2): 127-135.

• Aristotelia chilensis
• anti-inflammatory activity
• antioxidants
• DPPH
• crocin
• TBARS

Context: "Chilean Black-berry" Aristotelia chilensis is a wild fruit that growth in southern Chile. This fruit possess a strong antioxidant activity and is commonly used in foods and beverages in Chile. Objective: The anti-inflammatory activity of the extracts, fractions and subfractions of this fruit are investigated here for the first time. Materials and methods: Extracts, fractions and subfractions were analyzed for their content in total phenolics and the effects in the TPA-induced inflammation in ear of the mouse ear edema induced by single doses of TPA were investigated. In addition, the antioxidant activity was investigated against DPPH, Crocin and TBARS. Results: The results showed that extract B, fraction F-4, and ovatifolin, quercetin, myricetin, luteolin and diosmetin used as pattern compounds were the most active samples together with those subfractions rich in phenolic compounds. Thus, SF(11)-SF(15), SF(16)-SF(20), and SF(21)-SF(25) showed are the best subfractions inhibitors in similar form to indomethacin a known selective COX inhibitor that have an EI(50) of 0.11 mg/ear. Results demonstrated that these samples strongly inhibited the induced inflammation in ear of the mouse edema in TPA inflammation model, with EC(50) values ranging from 0.3 to 11.8 mu g/mL. Discussion and conclusion: These findings demonstrate that the fruits and their constituents of A. chilensis have excellent anti-inflammatory activities and thus have great potential as a source for natural health products. Additionally, these findings showed that the flavonoids, phenolic acids and anthocyanins present in this fruit may be responsible of the antioxidant activity observed.

• 出版日期2010-3