NutriTRAILomics in prostate cancer: time to have two strings to one's bow

作者：Farooqi Ammad Ahmad^*; Rana Aamir; Riaz Asma M; Khan Ammara; Ali Muhammad; Javed Sara; Mukhtar Shahzeray; Minhaj Sehrish; Rao Javeria Rafique; Rajpoot Javairia; Amber Rafia; Javed Fiza Asif; Waqar un Nisa; Khanum Reema; Bhatti Shahzad

来源：Molecular Biology Reports, 2012, 39(4): 4909-4914.

DOI：10.1007/s11033-011-1286-0

• Prostate cancer
• TRAIL
• Resveratrol
• EGCG

The astonishing development of broad genomics and proteomics tools have catalyzed a new era in both therapeutic interventions and nutrition in prostate cancer. The terms pharmacogenomics and nutrigenomics have been derived out of their genetic forbears as large-scale genomics technologies have been established in the last decade. It is unquestionable that rationale of both disciplines is to individualize or personalize medicine and food and nutrition, and eventually health, by tailoring the drug or the food to the individual genotype. The purpose of this review is to significantly inspect results from current research concerning the mechanisms of action of phytonutrients and potential effects on prostate cancer. Substantial emerging data supports the synergistic adiministration of nutraceuticals with TRAIL in prostate cancer progression to circumvent TRAIL refractoriness. Nonetheless, developing novel scientific methods for discovery, validation, characterization and standardization of these multicomponent phyto-therapeutics is vital to their recognition into mainstream medicine. The key to interpret a personalized response is a greater comprehension of nutrigenomics, proteomics and metabolomics.

• 出版日期2012-4