Pyrrolidine-pyridine base catalysts for the enantioselective Michael addition of ketones to chalcones

作者：Xu Da Zhen; Shi Sen; Liu Yingjun; Wang Yongmei^*

来源：Tetrahedron, 2009, 65(45): 9344-9349.

DOI：10.1016/j.tet.2009.09.001

A series of pyrrolidine-pyridine base organocatalysts have been developed and 3a found to be a highly effective catalyst for the asymmetric Michael addition reactions of ketones to chalcones. The reaction generated the corresponding products 1, 5-diketones in excellent diastereoselectivities (up to >99:1 dr) and enantioselectivities (up to 100% ee).

• 出版日期2009-11-7
• 单位南开大学