A mitochondria-targeted fluorescent probe for imaging endogenous malondialdehyde in HeLa cells and onion tissues

作者：He, Longwei; Yang, Xueling; Xu, Kaixin; Lin, Weiying^*

来源：Chemical Communications, 2017, 53(29): 4080-4083.

DOI：10.1039/c7cc00512a

• PERFORMANCE LIQUID-CHROMATOGRAPHY
• COMPLEMENT FACTOR-H
• LIPID-PEROXIDATION
• REACTIVE ALDEHYDE
• DNA ADDUCT
• SUPERRESOLUTION
• MECHANISM
• PROTEINS
• STRESS
• M(1)DG

The mitochondria-targeted turn-on fluorescent probe (Mito-FMP) based on a benzoxadiazole platform was developed for detection of malondialdehyde (MDA). Mito-FMP performed with large enhancement of the optical signal (774-fold) in response to MDA in an aqueous system and has the capability of monitoring endogenous MDA in HeLa cells and onion tissues.

• 出版日期2017-4-14
• 单位济南大学