Access to Several Polymorphic Forms of (+/-)-Modafinil by Using Various Solvation-Desolvation Processes

作者：Mahieux Julien; Sanselme Morgane^*; Coquerel Gerard

来源：Crystal Growth & Design, 2016, 16(1): 396-405.

DOI：10.1021/acs.cgd.5b01384

The solid state landscape of (+/-)-modafinil presents several polymorphic forms and solvates. Some of these polymorphic forms ((+/-)-Forms V and VI) can only be obtained by means of desolvation of solvates ((+/-)-modafinil chloroform solvate and acetonitrile solvate). Moreover, a new hydrate ((+/-)-modafinil monohydrate) is obtained from an original protocol which uses a physical mixture of both enantiomers rather than the racemic compound. All these solvates present an efflorescent behavior, and this study highlights the formation of various polymorphic forms from the same solvate according to the temperature of desolvation. Indeed, when the desolvation process is performed below or above the glass transition temperature (T-g) of the anhydrous modafinil, the resulting nonsolvated phases differ.

• 出版日期2016-1