ApoE and TDP-43 neuropathology in two siblings with familial FTLD-motor neuron disease

作者：Vossel Keith A; Bien Ly Nga; Bernardo Aubrey; Rascovsky Katya; Karydas Anna; Rabinovici Gil D; Sidhu Manu; Huang Eric J; Miller Bruce L; Huang Yadong; Seeley William W^*

来源：Neurocase, 2013, 19(3): 295-301.

DOI：10.1080/13554794.2012.667124

• Apolipoprotein E
• TDP-43
• Frontotemporal dementia
• Motor neuron disease
• Neuropathology

Frontotemporal lobar degeneration with motor neuron disease (FTLD-MND) is characterized by neuronal cytoplasmic inclusions containing TDP-43. Apolipoprotein E4 (apoE4), derived from the apoE E4 allele, enhances brain atrophy in FTLD through unknown mechanisms. Here, we studied two siblings with C9ORF72-linked familial FTLD-MND, an apoE E4 homozygote and an apoE E3 homozygote. The apoE E4 homozygote had more cognitive-behavioral symptoms, fronto-insulo-temporal atrophy, and apoE fragments and aggregates in the anterior cingulate cortex. ApoE formed complexes with TDP-43 that were more abundant in the apoE E4 homozygote. Although differences seen in a sibling pair could arise due to chance, these findings raise the possibility that apoE4 exacerbates brain pathology in FTLD through formation of neurotoxic apoE fragments and interactions with TDP-43.

• 出版日期2013-6-1