High frequency resonant waveguide grating imager for assessing drug-induced cardiotoxicity

作者：Ferrie Ann M; Wu Qi; Deichmann Oberon D; Fang Ye

来源：Applied Physics Letters, 2014, 104(18): 183702.

DOI：10.1063/1.4876095

We report a high-frequency resonant waveguide grating imager for assessing compound-induced cardiotoxicity. The imager sweeps the wavelength range from 823 nm to 838 nm every 3 s to identify and monitor compound-induced shifts in resonance wavelength and then switch to the intensity-imaging mode to detect the beating rhythm and proarrhythmic effects of compounds on induced pluripotent stem cell-derived cardiomyocytes. This opens possibility to study cardiovascular biology and compound-induced cardiotoxicity.

• 出版日期2014-5-5