Novel isocyanide-based three-component reaction: a facile synthesis of substituted 1H-chromeno[2,3-d]pyrimidine-5-carboxamides

作者：Soleimani Ebrahim^*; Ghorbani Somayeh; Ghasempour Hamid Reza

来源：Tetrahedron, 2013, 69(39): 8511-8515.

DOI：10.1016/j.tet.2013.06.080

• Chromeno[2,3-d]pyrimidine
• Multicomponent reactions
• Benzopyran
• Salicylaldehyde
• Barbituric acid
• Isocyanide

A mild and efficient method for the synthesis of 1H-chromeno[2,3-d]pyrimidine-5-carboxamide derivatives via a one-pot, three-component reaction of an isocyanide, barbituric acid, and a salicylaldehyde in the presence of acetic acid in ethanol/water mixture at 75 degrees C is reported. This high atom economy reaction led to the construction of one benzopyran ring, and one amide group in a single synthetic step.

• 出版日期2013-9-30