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摘要
This study assessed the mixture health risk for the residents of China's Lake Taihu region posed by a Persistent Organic Pollutants (POPs) mixture of dichlorodiphenyl-trichloroethane (DDT) and hexachlorocyclohexane (HCH). Multiple-pathway exposure models were used for exposure assessment in order to estimate the DDT and HCH exposure dose. The DDT and HCH PBPK models were developed and used for consequence assessment in order to analyze the pollutant distribution and accumulation process in human tissues. The tissue dose hazard index (HI) was used to estimate the mixture health risk. The results showed that the total exposure doses for male residents and female residents were 4.01 x 10(-4) x 7.67 x 10(-3) mg/kg/day and 3.73 x 10(-4) similar to 6.75 x 10(-3) mg/kg/day for DDT, respectively, and 3.78 x 10(-4) similar to 5.14 x 10(-3) mg/kg/day and 3.53 x 10(-4) similar to 4.66 x 10(-3) mg/kg/day for HCH, respectively. The maximum tissue concentrations in fat for male and female residents reached 110.51 mg/l and 97.21 mg/l for DDT, respectively, and 189.66 mg/l and 171.72 mg/l for HCH, respectively. The tissue dose hazard indexes for male and female residents were 0.1472 similar to 2.4990 and 0.1377 similar to 2.2230, respectively, and the probabilities of the risk exceeding the acceptable risk (HI = 1) for male and female were 24.60% and 16.51%, respectively.
- 出版日期2009
- 单位环境保护部华南环境科学研究所; 中山大学
