A practical and green approach towards synthesis of multisubstituted imidazoles using boric acid as efficient catalyst

作者:Zhang, Feifei; Gao, Qi; Chen, Bang; Bai, Yinjuan*; Sun, Wei; Lv, Dongxu; Ge, Man
来源:Phosphorus, Sulfur, and Silicon and the Related Elements, 2016, 191(5): 786-789.
DOI:10.1080/10426507.2015.1100184

摘要

An efficient one-pot' cyclocondensation of ammonium acetate, 7 2-diphenyl ethanedione, aromatic aidehyde or arylamine, and catalyzed by boric acid is achieved to form multisubstituted imidazole derivatives. Boric acid as green property is harmless to the environment has improved the yield of multisubstituted imidazole derivatives. Moreover, we have tested the biological activities of imidazole derivatives by the four fungi. And the investigations showed most of imidazole derivatives have antifungal action on four fungus.

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