Asymmetric total syntheses of heliannuol E and epi-heliannuol E

作者：Liu Yongjiang; Huang Chong; Liu Bo^*

来源：Tetrahedron Letters, 2011, 52(44): 5802-5804.

DOI：10.1016/j.tetlet.2011.08.131

• Heliannuol E
• Total synthesis
• Natural product
• Sesquiterpene

Asymmetric total syntheses of heliannuol E and epi-heliannuol E were achieved in 10 and 13 steps, respectively, from the commercially available starting materials. The syntheses feature an intramolecular attacking on the sulfate to form the dihydropyran ring of heliannuol E and an acyl transfer-secondary carbocation capture sequence to construct the dihydropyran ring of epi-heliannuol E.

• 出版日期2011-11-2
• 单位四川大学