Association of HPV infections with second primary tumors in early-staged oral cavity cancer

作者：Huang S F; Li H F; Liao C T; Wang H M; Chen I H; Chang J T C; Chen Y J; Cheng A J^*

来源：Oral Diseases, 2012, 18(8): 809-815.

DOI：10.1111/j.1601-0825.2012.01950.x

• human papilloma virus
• oral cavity cancer
• secondary malignancy
• risk exposure
• clinical association

Oral Diseases (2012) 18, 809815 Objective: The infection of human papilloma virus (HPV) has been reported in head and neck cancer; however, the clinical significance of HPV infection on the pathogenesis of oral cavity squamous cell carcinoma (OSCC) is still uncertain. Materials and Methods: The study recruited 103 patients with pathological early-stage OSCC between March 1997 and December 2003 from Chang Gung Memorial Hospital, Taiwan. Tumor specimens were HPV-genotyped by the EasychipVR HPV Blot method. Clinical association study was performed by using chi-square, KaplanMeier, and logrank tests. Results: Thirty-one patients (30.1%) were positive for HPV infection. The most frequent HPV types were types 16 (16 patients, 51.6%) and 18 (seven patients, 22.6%). HPV infection was not associated with tumor aggressiveness (pathological tumor stage or differentiation status), risk exposure (alcohol, cigarette, or areca quid chewing habit), or the treatment outcome (disease-free survival or overall survival). However, infection with HPV-18 was associated with the occurrence of a second primary cancers (P = 0.033), indicating the infection of HPV in OSCC enhances the susceptibility of developing secondary malignancy. Conclusions: There are 30% of the patients with OSCC infected with HPV, with most high-risk types. HPV-18 infection may enhance the susceptibility of second primary tumors. Large scale of validation study will be needed to confirm this result.

• 出版日期2012-11
• 单位长春大学