Low levels of vitamin D are associated with multimorbidity: Results from the LifeLines Cohort Study

作者：Meems Laura M G; de Borst Martin H; Postma Dirkje S; Vonk Judith M; Kremer Hubertus P H; Schuttelaar Marie Louise A; Rosmalen Judith G M; Weersma Rinse K; Wolffenbuttel Bruce H R; Scholtens Salome; Stolk Ronald P; Kema Ido P; Navis Gerjan; Khan Mohsin A F; van der Harst Pim; de Boer Rudolf A

来源：Annals of Medicine, 2015, 47(6): 474-481.

DOI：10.3109/07853890.2015.1073347

• Co-morbidity
• 25-hydroxyvitamin D
• LifeLines Cohort Study
• morbidity
• multimorbidity
• vitamin D
• vitamin D deficiency

Background. The prevalence of multimorbidity (>= 1 disease within an individual) is rapidly increasing. So far, studies on the relationship between vitamin D and morbidity are mainly focusing on effects on single disease domains only, while vitamin D biology is associated with several diseases throughout the human body.
Methods. We studied 8,726 participants from the LifeLines Cohort Study (a cross-sectional, population-based cohort study) and used the self-developed composite morbidity score to study the association between vitamin D levels and multimorbidity.
Results. Study participants (mean age 45 +/- 13 years, 73% females) had a mean plasma vitamin D level of 59 +/- 22 nmol/L. In participants aged between 50 and 60 years, 58% had >= 2 affected disease domains, while morbidity score increased with age (70-80 years: 82% morbidity score > 1; > 80 years: 89% morbidity score > 1). Each incremental reduction by 1 standard deviation (SD) of vitamin D level was associated with an 8% higher morbidity score (full model OR 0.92, 95% CI 0.88-0.97, P = 0.001). Participants with vitamin D levels < 25 nmol/L were at highest risk for increasing morbidity prevalence (versus > 80 nmol/L, OR 1.34, 95% CI 1.07-1.67, P = 0.01).
Conclusions. Low levels of vitamin D are associated with higher prevalence of multimorbidity, especially in participants with vitamin D levels < 25 nmol/L. Collectively, our results favor a general, rather than an organ-specific, approach when assessing the impact of vitamin D deficiency.

• 出版日期2015