An efficient procedure for preparation of 2-monoalkyl or 2-monoaryl-3-ethoxycyclobutanones

作者：Matsuo Jun ichi^*; Okuno Ryosuke; Takeuchi Kosuke; Kawano Mizuki; Ishibashi Hiroyuki

来源：Tetrahedron Letters, 2010, 51(29): 3736-3737.

DOI：10.1016/j.tetlet.2010.05.031

Optimized reaction conditions for the preparation of various 2-monosubstituted 3-ethoxycyclobutanones are described. 2-Monoalkyl 3-ethoxycyclobutanones were efficiently prepared by the reaction of the corresponding carboxylic acid chlorides and an excess amount of ethyl vinyl ether in the presence of diisopropylethylamine at 90 degrees C in a sealed tube. 2-Monoaryl 3-ethoxycyclobutanones were prepared by using 2,6-lutidine as a base in the above-mentioned procedure.

• 出版日期2010-7-21
• 单位河北医科大学