Amyotrophic lateral sclerosis in Sardinia (Italy): epidemiologic features from 1957 to 2000

作者：Giagheddu M^*; Puggioni G; Tacconi P; Pirastru M I; Cannas A; Tamburini G; Congia S

来源：Acta Neurologica Scandinavica, 2013, 127(4): 251-259.

DOI：10.1111/j.1600-0404.2012.01705.x

• amyotrophic lateral sclerosis
• motor neuron diseases
• epidemiology

Giagheddu M, Puggioni G, Tacconi P, Pirastru MI, Cannas A, Tamburini G, Congia S. Amyotrophic lateral sclerosis in Sardinia (Italy): epidemiologic features from 1957 to 2000. Acta Neurol Scand: 2013: 127: 251-259. (C) 2012 John Wiley %26 Sons A/S. Objectives To evaluate epidemiological variables of amyotrophic lateral sclerosis (ALS) in Sardinia (Italy) in the 19912000 periods and compare them with the preceding decades. Material and methods Survey, critical reappraisal or clinical re-evaluation of all ALS cases with onset in the decade 19912000; calculation of crude and age-adjusted incidence, duration of disease, survival rates and the latency between onset of symptoms and diagnosis. Results A significant increase in the mean annual incidence was observed in comparison with the values found in the two previous decades, 19711980 and 19811990. The distribution of the disease in various areas of the island was found to be not at all homogeneous. No significant modifications of the duration of the disease and survival rates were observed. Conclusion The role of particular exogenous factors, albeit still unclear, can be invoked.

• 出版日期2013-4