Accumulation and local proliferation of antigen-specific CD4(+) T cells in antigen-bearing tissue

作者：Doebis Cornelia; Menning Astrid; Neumann Katrin; Ghani Saeed; Schlawe Kerstin; Lauer Uta; Hamann Alf; Huehn Jochen; Syrbe Uta^*

来源：Immunology and Cell Biology, 2011, 89(4): 566-572.

DOI：10.1038/icb.2010.128

• inflammation
• migration
• proliferation
• T-cell accumulation
• skin

Although activation and subsequent expansion of naive CD4(+) T cells within lymph nodes is well characterized, the fate of T effector cells activated within peripheral tissues during secondary reactions is poorly defined. Therefore, we studied the recruitment, proliferation and egress of antigen-specific Th1 effector cells in comparison with nonspecific Th1 cells throughout a delayed-type hypersensitivity reaction (DTH). Although we observed a high turnover of Th1 effector cells with unspecific high-rate recruitment and CCR7-dependent egress from the inflamed tissue in the early, acute DTH phase, a strong, selective accumulation of antigen-specific T cells occurred during the chronic, late DTH phase. This was mainly based on local proliferation of CD4(+) effector cells within the DTH tissue and concomitant retention. Considering the strong CCR7-dependent Th cell egress found in this model, the reduced CCR7 expression on antigen-specific T cells isolated from late-phase DTH tissue most likely contributes to the retention of these cells within the tissue. Thus, peripheral tissues can support not only the proliferation of CD8(+) T cells, as recently shown, but also that of CD4(+) T effector cells, forming a pool of tissue-resident T cells. Immunology and Cell Biology (2011) 89, 566-572; doi:10.1038/icb.2010.128; published online 9 November 2010

• 出版日期2011-6