Procollagen type 1 amino-terminal propeptide (P1NP) and risk of hip fractures in elderly Norwegian men and women. A NOREPOS study

作者：Finnes T E^*; Lofthus C M; Meyer H E; Eriksen E F; Apalset E M; Tell G S; Torjesen P; Samuelsen S O; Holvik K

来源：Bone, 2014, 64: 1-7.

DOI：10.1016/j.bone.2014.03.010

• Bone turnover marker
• Procollagen type 1 amino-terminal propeptide
• Hip fractures
• Osteoporosis
• Elderly

The current study aimed to assess a possible association between the bone turnover marker procollagen type 1 amino-terminal propeptide (P1NP) and future hip fractures in elderly Norwegian men and women and to elucidate the relation between P1NP, bone mineral density and 25-hydroxyvitamin D (25(OH)D). Men and women aged 71 to 77 from two population based health studies in Norway (1999-2001) were followed for a median period of 7.3 years with respect to hip fractures. The study was designed as a case-cohort study. P1NP and 25 (OH)D were analysed in frozen serum samples obtained at baseline in hip fracture patients (n = 340) and in randomly selected sex stratified sub-cohorts. Bone mineral density was measured by dual-energy X-ray absorptiometry (DXA) in a subset of participants. Cox proportional hazards regression with inverse probability weighting and robust variance was performed. No significant correlation between 25(OH)D and P1NP was found. A negative correlation between P1NP and BMD was observed in women (Rho = -0.36, p = 0.001). A similar trend was observed in men. No association between quartiles of P1NP and rate of subsequent hip fractures was found. Spline analyses suggested a higher rate of hip fracture at P1NP levels above 60 mu g/L in both men and women. A higher hip fracture rate, which was independent of BMD, was also indicated in women with very low levels of P1NP.

• 出版日期2014-7