A natural herbal remedy modulates angiogenic activity of bronchoalveolar lavage cells from sarcoidosis patients

作者：Radomska Lesniewska Dorota M; Skopinska Rozewska Ewa; Demkow Urszula; Jozwiak Jaroslaw; Sobiecka Malgorzata; Balan Barbara Joanna^*

来源：Central European Journal of Immunology, 2016, 41(1): 25-30.

DOI：10.5114/ceji.2016.58311

• sarcoidosis
• bronchoalveolar lavage cells
• BAL
• herbal remedy
• leukocyte-induced angiogenesis
• LIA
• murine skin

Sarcoidosis is a systemic inflammatory disease with abnormally high angiogenic activity of inflammatory cells. Reumaherb preparation consisting of three herbs: Echinacea purpurea, Harpagophytum procumbens, and Filipendula ulmaria, and it exerts anti-inflammatory, antioxidant, and analgesic activity and stimulates regenerative and immunological processes.
The aim of this paper was to estimate the effect of Reumaherb on immunological angiogenesis induced by bronchoalveolar lavage (BAL) cells collected from six patients with sarcoidosis and grafted into Balb/c mice skin. After grafting, the animals were fed for three days with 0.6 or 1.2 mg of Reumaherb (calculated from recommended human daily dose) daily, suspended in 40 mu l of water, or 40 mu l of water alone (control group).
A significant reduction of newly formed blood vessels was obtained in four cases for 1.2 mg and in three cases for 0.6 mg daily dose of this remedy. Thus, we hypothesise that Reumaherb promotes anti-angiogenic activity and may potentially be used in diseases associated with excessive blood vessel formation.

• 出版日期2016