Association between -238 but not -308 polymorphism of Tumor necrosis factor alpha (TNF-alpha)v and unexplained recurrent spontaneous abortion (URSA) in Chinese population

作者：Liu, Chunmei; Wang, Jing; Zhou, Sirui; Wang, Binbin^*; Ma, Xu

来源：Reproductive Biology and Endocrinology, 2010, 8(1): 114.

DOI：10.1186/1477-7827-8-114

• CYTOKINE GENE POLYMORPHISMS
• PREGNANCY LOSS
• TNF-ALPHA
• MISCARRIAGE
• EXPRESSION
• HISTORY

Objectives: TNF-alpha is a critical cytokine produced by Th1 cells while altered T helper 1 (Th1)-Th2 balance is found crucial for a successful pregnancy.
Study Design: A cohort of 132 Southern Chinese Han RSA patients and 152 controls constituted the subjects of this study. Two functional polymorphisms -308 and -238 of TNF-alpha were studied by association analysis.
Results: lack of association was found in TNF-alpha -308 SNP yet a significant difference was discovered in -238 polymorphism.
Conclusion: This study suggested that TNF-alpha may be a risk factor in Chinese RSA patients. However the ethnic differences may also contribute to the results.

• 出版日期2010-9-28
• 单位国家卫生计生委科学技术研究所; 中国医学科学院北京协和医院