Antibody-dependent cellular cytotoxicity and influenza virus

作者：Vanderven Hillary A; Jegaskanda Sinthujan; Wheatley Adam K; Kent Stephen J

来源：Current Opinion in Virology, 2017, 22: 89-96.

DOI：10.1016/j.coviro.2016.12.002

Antibodies are a key defence against influenza infection and disease, but neutralizing antibodies are often strain-specific and of limited utility against divergent or pandemic viruses. There is now considerable evidence that influenza-specific antibodies with Fc-mediated effector functions, such as antibody-dependent cellular cytotoxicity (ADCC), can assist in the clearance of influenza infection in vitro and in animal models. Further, ADCC-mediating antibodies that recognize a broad array of influenza strains are common in humans, likely as a result of being regularly exposed to influenza infections. The concept that influenza-specific ADCC can assist in the partial control of influenza infections in humans is gaining momentum. This review examines the utility of influenza specific ADCC antibodies.

• 出版日期2017-2