Axially chiral biscarbazoles and biological evaluation of the constituents from Murraya koenigii

作者：Uvarani Chokkalingam; Jaivel Nanjundan; Sankaran Mathan; Chandraprakash Kumarasamy; Ata Athar^*; Mohan Palathurai Subramaniam

来源：Fitoterapia, 2014, 94: 10-20.

DOI：10.1016/j.fitote.2014.01.004

• Murraya koenigii
• Biscarbazoles
• Antioxidant
• alpha-Glucosidase inhibition
• DNA and protein binding
• Cytotoxicity

Chemical investigation of the fruit pulp of Murraya koenigii resulted in the identification of two new dimeric carbazole alkaloids, bisgerayafoline D (1) and bismahanimbinol (2) along with four known alkaloids, bispyrayafoline (3), O-methyl mahanine (4), O-methyl mukonal (5), and mahanine (6): Structures of 1-6 were determined with the aid of UV, IR, Mass and extensive NMR spectroscopic studies. Absolute configurations of biaryls in 1 and 2 were assigned using a combination of computational Circular Dichroism (CD) and experimental electronic CD spectroscopic data. Compounds 1-6 were evaluated for anti-oxidant, anti-a-glucosidase, DNA binding, protein interactions and cytotoxic activities. Among all the isolates, mahanine (6) was found to exhibit significant radical scavenging and a-glucosidase inhibitory activities. Compound 6 was also found to be active in cytotoxicity assay against three human cancer cell lines HeLa, HCT116, AGS and this compound was weakly active against normal mouse embryonic fibroblasts (NIH3T3).

• 出版日期2014-4