Bone reconstruction: Au nanocomposite bioglasses with antibacterial properties

作者：Grandi Stefania; Cassinelli Valentina; Bini Marcella; Saino Enrica; Mustarelli Piercarlo; Arciola Carla Renata; Imbriani Marcello; Visai Livia^*

来源：The International Journal of Artificial Organs, 2011, 34(9): 920-928.

DOI：10.5301/ijao.5000059

• Bioglass
• Gold nanoparticles
• Sol-gel
• Antibacterial activity

Bioglasses are of wide interest since they spontaneously bond and integrate with living bone in the body. By varying the glass chemistry and/or by adding some dopants, it is possible to improve their clinical applications. Gold nanoparticles (Au NPs) are a well-known antibacterial agent, as well as a unique probe for sensing and imaging applications. We report on the synthesis of a 58S bioglass doped with Au NPs at two doping levels: 0.1% wt. and 1% wt. Antibacterial properties were observed on the Gram-positive Staphylococcus aureus, whereas no significant effects were found on the Gram-negative Escherichia coli. A possible mechanism of action of Au NPs towards bacteria has been described.

• 出版日期2011-9
• 单位常州工学院