Uric acid and clinical correlates of endothelial function in kidney transplant recipients

作者：Dahle Dag Olav^*; Jenssen Trond; Holdaas Hallvard; A**erg Anders; Soveri Inga; Holme Ingar; Mjoen Geir; Eide Ivar A; Pihlstrom Hege; Doerje Christina; Halden Thea A S; Hartmann Anders

来源：Clinical Transplantation, 2014, 28(10): 1167-1176.

DOI：10.1111/ctr.12435

• EndoPAT
• endothelial function
• flow-mediated dilatation
• kidney transplant recipients
• uric acid

Uric acid is associated with increased mortality in kidney transplant recipients (KTRs), but it is uncertain if this involves endothelial dysfunction. We hypothesized, first, that there was an association between uric acid and endothelial function, and second, that there were associations between endothelial function and cardiac and mortality risk scores.
MethodsOne hundred and fifty-two patients were examined 10wk after kidney transplantation by two measures of endothelial function, the brachial artery flow-mediated dilatation (FMD) expressed as percent dilatation (FMD%), and fingertip peripheral arterial tone (PAT) expressed as log-reactive hyperemia index (LnRHI). Risk scores were calculated from a recently validated formula. Other clinical correlates of endothelial function were described in stepwise linear regression models.
ResultsUric acid was associated negatively with FMD% in an age- and gender-adjusted model, while not in the multivariable model. No association was shown between uric acid and LnRHI. FMD% was associated negatively with risk scores in both crude and age- and gender-adjusted models (p<0.01). LnRHI was associated negatively with risk scores in the latter model only (p<0.05).
ConclusionsUric acid was neither associated with FMD% nor LnRHI in KTRs. There were significant associations between endothelial function indices and cardiac and mortality risk scores.

• 出版日期2014-10