摘要

In order to avoid the aggregation and/or fusion of the polyelectrolyte multilayer hollow microcapsules self-assembled via the noncovalent bonds, superparamagnetic polyelectrolyte hybrid hollow microcapsules surface modified with polyethylene glycol (PEG) brushes were designed and fabricated. After the layer-by-layer (LbL) self assembly of chitosan (CS) and citric acid modified magnetic nanoparticles (Fe3O4-CA) as the polycation and the hybrid anion on the polystyrene sulfonate microsphere (PSS) templates, respectively, the aldehyde group terminated polyethylene glycol 4000 (APEG) was grafted onto the surface of the superparamagnetic polyelectrolyte hybrid multilayer coated template microspheres via the nucleophilic addition between the aldehyde groups of APEG and the amino groups of CS. Then, the modified superparamagnetic polyelectrolyte hybrid hollow microcapsules were obtained after the templates were removed by dialysis. It was found that the surface PEGylation could prevent aggregation among the hollow microcapsules in the media with high salt concentration by dynamic light scattering (DLS), besides the increase in biocompatibility. The technique developed is expected to realize the application of the polyelectrolyte multilayer hollow microcapsules in real physiological environments.