A nonenzymatic sensor for xanthine based on electrospun carbon nanofibers modified electrode

作者：Tang, Xiaofeng; Liu, Yang; Hou, Haoqing; You, Tianyan^*

来源：Talanta, 2011, 83(5): 1410-1414.

DOI：10.1016/j.talanta.2010.11.019

• Carbon nanofibers
• Electrospinning
• Xanthine
• Electrocatalytic oxidation

Xanthine (Xa) determination is of considerable importance in clinical analysis and food quality control. Therefore, a sensitive nonenzymatic amperometric sensor for Xa based on carbon nanofibers (CNFs) has been proposed. The CNFs, which were prepared by electrospinning technique and subsequent thermal treatment, were used to modify carbon paste electrode (CNF-CPE) to construct the amperometric sensor device without any oxidation pretreatment. In application to Xa electrochemical determination, the CNF-CPE exhibited high electrocatalytic activity and fast amperometric response. Various experimental parameters, such as pH and applied potential were optimized. Under the optimal conditions, the dynamic linear range of Xa was 0.03-21.19 mu M (R = 0.9992) with the detection limit low to 20 nM (S/N = 3). With good selectivity and sensitivity, the present system was successfully applied to estimate the freshness of fish and determine Xa in human urine, which provides potential application in food quality control and clinical analysis.

• 出版日期2011-2-15
• 单位中国科学院长春应用化学研究所; 聊城大学; 电分析化学国家重点实验室; 江西师范大学