Antimicrobial activity of allylic thiocyanates derived from the Morita-Baylis-Hillman reaction

作者：Sa Marcus Mandolesi^*; Ferreira Misael; Lima Emerson Silva; Dos Santos Ivanildes; Orlandi Patrcia Puccinelli; Fernandes Luciano

来源：Brazilian Journal of Microbiology, 2014, 45(3): 807-812.

DOI：10.1590/s1517-83822014000300007

• antimicrobial
• allylic thiocyanate
• Morita-Baylis-Hillman reaction
• MRSA

Bacterial resistance to commonly used antibiotics has been recognized as a significant global health issue. In this study, we carried out the screening of a family of allylic thiocyanates for their action against a diversity of bacteria and fungi with a view to developing new antimicrobial agents. Allylic thiocyanates bearing halogenated aryl groups, which were readily obtained in two steps from the Morita-Baylis-Hillman adducts, showed moderate-to-high activity against selective pathogens, including a methicillin-resistant S. aureus (MRSA) strain. In particular cases, methyl (Z)-3-(2,4-dichlorophenyl)-2-(thiocyanomethyl)-2-propenoate exhibited antimicrobial activity comparable to the reference antibiotic Imipenem.

• 出版日期2014-9