A Facial Protocol for the Synthesis of Benzofuran Derivatives by the Reaction of o-Hydroxy Aryl Ketone, Amine and Chloroacetyl Chloride

作者:Xia, Shuai; Wang, Xiu-Hua; Liu, Ji-Qiang; Liu, Chang; Chen, Jian-Bin; Zuo, Hua*; Xie, Yong-Sheng; Dong, Wen-Liang; Shin, Dong-Soo
来源:BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2014, 35(6): 1743-1748.
DOI:10.5012/bkcs.2014.35.6.1743

摘要

A facile and effective method has been developed for the synthesis of a novel series of benzofuran derivatives via N-acylation, O-alkylation and intramolecular condensation reactions, starting from readily available substituted o-hydroxy aryl ketone, and chloroacetyl arylamides. This metal-free transition process is characterized by mild reaction conditions, atom economy, short reaction time and a high yield with a decreased amount of by-products.