Angiogenesis as a target in neuroblastoma

作者：Roessler Jochen; Taylor Melissa; Geoerger Birgit; Farace Francoise; Lagodny Jeanette; Peschka Suess Regine; Niemeyer Charlotte M; Vassal Gilles

来源：European Journal of Cancer, 2008, 44(12): 1645-1656.

DOI：10.1016/j.ejca.2008.05.015

• angiogenesis
• neuroblastoma
• anti-angiogenesis
• VEGF
• bevacizumab

Several research investigations on neuroblastoma (NB) have shown the important dependency of this embryonic tumour on angiogenesis, especially in the advanced and aggressive stages. However, the first pre-clinical data on anti-angiogenic drugs in NB have not been published until recently and clinical trials with anti-angiogenic agents in NB treatment protocols are still missing.
Here, we summarise current knowledge on the important role and mechanisms of angiogenesis in NB, and report available pre-clinical results of anti-angiogenic agents used to treat NB. This review clearly shows that angiogenesis is a target in NB and that clinical trials are urgently needed to bring forward promising anti-angiogenesis treatment strategies into NB therapy.

• 出版日期2008-8